Study on the Interaction between ¦Â-Cyclodextrin and Naproxen by Two dimensional Diffusion Ordered NMR Spectroscopy

KeyWord:diffusion ordered NMR spectroscopy£¨DOSY)  self-diffusion  naproxen  ¦Â CD  inclusion interaction

Abstract:

      The interaction between naproxen and cyclodextrin was studied by two-dimensional diffusion ordered£¨2D-DOSY) NMR spectroscopy.Influences of different factors on the self-diffusion coefficient and the equilibrium constant were investigated.The results showed that the increase of temperature,water content,pH and ionic strength had more influence on the self-diffusion coefficient of the guest than that of the host£¬which could increase the equilibrium constants.The inclusion interaction was the strongest in a solution of pH 9.0.The results of thermodynamic analysis showed that the inclusion process was spontaneous and endothermic entropy-driven process,and the main active force was the hydrophobic force.