Determination of Three Chloropropanols in Condimen by Gas Chromatography-Tandem Mass Spectrometry

KeyWord:gas chromatography-tandem mass spectrometry  condimen  1,3-dichloro-2-propanol  2,3-dichloro-1-propanol  3-chloro-1,2-propanediol  multiple-reaction monitoring

Abstract:

      A method was developed for the determination of 1,3-dichloro-2-propanol£¨1,3-DCP£©,2,3-dichloro-1-propanol£¨2,3-DCP£© and 3-chloro-1,2-propanediol£¨3-MCPD£© in condimen by gas chromatography-tandem mass spectrometry£¨GC-MS/MS£©.The conditions for sample pretreatment and GC-MS/MS were investigated and optimized.The samples were purified by kieselguhr£¬eluted with hexane-diethyl ether£¨5¡Ã5£©£¬then derivatised by trifluoroacetic acid anhydride.The detection was carried out by GC-MS/MS in the multiple-reaction monitoring£¨MRM£© mode.Good linear relationships of three analyte were obtained in the concentration range of 0.001-10 mg/L£¬with correlation coefficients of 0.999 8£¬0.999 6 and 0.999 7£¬respectively.The limits of detection were all 0.000 5 mg/kg£¨S/N=3£©£¬and the recoveries ranged from 88% to 97%£¨n=6£©.This method is simple£¬rapid£¬low solvent consumption£¬cheap price of derivative£¬and the complex matrix disturbance in condimen samples was diminished when MRM mode was adopted.The accuracy,reliability and sensitivity of the method made it was suitable for the determination of three chloropropanols in condimen samples.