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Determination of 24 Allergens in Suspicious Cosmetics by Gas Chromatography-Mass Spectrometry |
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DOI:10.3969/j.issn.1004-4957.年份.月份 |
KeyWord:gas chromatography-mass spectrometry cosmetics allergen contact dermatitis |
Author | Institution |
陈捷,焦红,叶弘毅,毕英杰,刘超,郑璇,战静,赖唯 |
1.广州检验检疫技术中心;2.广东出入境检验检疫局;3.中山大学公共卫生学院;4.中山大学第三附属医院 |
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Abstract: |
A simultaneous determination method was developed for the reliable screening,quantification and confirmation of 24 allergens in cosmetics by gas chromatography-mass spectrometry(GC-MS).The 24 allergens were extracted from cosmetics with methanol,then determined by GC-MS with the external standard method under the selected ion mode(SIM).The calibration curves showed good linearities in the range of 0.2-100 mg/L with correlative coefficients (r2) larger than 0.995.The detection limits were in the range of 2-10 mg/kg,and the average recoveries were 80%-104% with relative standard deviations of 1.8%-9.3%.The method was rapid,accurate and sensitive.The positive detection rate of 24 allergens in 150 samples of 77 patients using cosmetics was 78%,and there was at least one allergen measured value above 10 mg/kg in 81.2% of the positive samples.24 allergens in the cosmetics used by 71 patients were detected out and the detection rate was 92.2%,which at least one allergen measured value above 10 mg/kg was 90.1%.24 allergens are the major allergens in cosmetic contact dermatitis. |
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