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Research Progress of Electrochemical Biosensor for Single Nucleotide Polymorphisms Detection |
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DOI:10.3969/j.issn.1004-4957.年份.月份 |
KeyWord:single nucleotide polymorphisms biosensor electrochemical detection signal amplification research progress |
Author | Institution |
封科军,李继山,蒋健晖,沈国励,俞汝勤 |
1.惠州学院化学工程系;2.湖南大学化学化工学院化学生物传感与计量学国家重点实验室 |
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Abstract: |
As the third generation of genetic marker,the analysis of single nucleotide polymorphisms (SNPs) has a great significance for the pathogeny and early medical diagnosis of gene diseases,and has become a hotspot of analytical chemistry and life science research.In recent years,the electrochemical biosensors have been widely used in SNPs assay due to its advantages of high-sensitivity,simple-design,low-cost,easy miniaturization and automation.In this paper,the principle of SNPs typing,electrochemical biosensor technology and signal amplification methods for SNPs are introduced.Moreover,the current research progress on electrochemical detection for SNPs is summarized,and the future direction of SNPs electrochemical detection is discussed. |
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