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| Study on the Adsorption of Cytochrome c on Graphene Oxide |
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| DOI：10.3969/j.issn.1004-4957.年份.月份 |
| KeyWord:graphene cytochrome c adsorption protein enzymatic activity |
| Author | Institution |
| 刘倩，殷诺雅，李卓娜，江桂斌 |
中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室 |
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| Abstract: |
| Investigation on the adsorption of proteins on graphene is very important for the biomedical applications and safety evaluation of graphene materials.In this work，the adsorption of cytochrome c，a protein involved in cell apoptosis，on graphene oxide was studied.The morphology of graphene oxide and its protein complex were characterized by atomic force microscopy，indicating that the adsorption occured in multilayer mode.The adsorption kinetics and isotherm were also studied，revealing a very high adsorption capacity(1 978 mg/g) of cytochrome c on graphene oxide.Finally，it is found that the enzymatic activity of cytochrome c only changed slightly before and after the adsorption on graphene oxide，suggesting that the conformation of cytochrome c was maintained during the adsorption process.This work is expected to provide some important data for biomedical applications and safety evaluation of graphene materials. |
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