Progresses on Synthesis Methods of Molecularly Imprinted Microspheres and Their Applications in Solid phase Extraction

KeyWord:molecularly imprinted microspheres£¨MIMs£©  suspension polymerization  multi-swelling polymerization  precipitation polymerization  solid-phase extraction  review

Abstract:

      Compared with bulk molecularly imprinted polymer£¬molecularly imprinted microspheres£¨MIMs£© exhibit more uniform size and much better dynamic characteristics.Thus£¬MIMs are widely used in the applications of solid-phase extraction£¨SPE£©£¬chromatographic separation£¬biosensor and drug delivery system.The main synthesis methods of MIMs are suspension polymerization£¬multi-swelling polymerization£¨MSP£© and precipitation polymerization£¨PP£©.In this review£¬the research literatures on MIMs published in recent 10 years were tracked.The three synthesis methods of MIMs were summarized and commented.The advantages and disadvantages of those synthesis methods were compared.Meanwhile£¬the applications of MIMs in SPE were reviewed£¬and the prospect of synthesis and applications of MIMs was also put forward.