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Electrochemical Analysis on the Interaction of Polymyxin B with Phosphatidylserine and Comparison to Other Phospholipids |
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DOI:10.3969/j.issn.1004-4957.年份.月份 |
KeyWord:polymyxin B phospholipid bilayer membrane phosphatidylserine cyclic voltammetry interaction |
Author | Institution |
屈凌波,冉瑜,白希希,牛真真,于岚岚 |
1.郑州大学化学系;2.河南工业大学化学化工学院 |
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Abstract: |
A stable phospholipid bilayer membrane was constructed on Au electrode surface by using a headgroup modified phospholipid and applied as a biomembrane model to investigate the interaction of an antibiotic polymyxin B with phosphatidylserine.Polymyxin B interacted with phosphatidylserine and destroyed the bilayer structure,resulting in increasing membrane permeation.The extent of interaction was dependent on polymyxin B concentration,reaction time and presence of cholesterol.The destroyed bilayer membrane could undergo self-recovery to some extent in KCl solution and the self-recovery was dependent on recovery time and concentration of polymyxin B.In addition,the interactions between PMB and different phospholipids were compared.Headgroup,alkyl chain length and saturation of phospholipid all affected the interaction. |
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