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Determination of Chlordimeform and Its Metabolite 4-Chloro-2-methylaniline Residues in Animal Derived Foods by Gas Chromatography-Mass Spectrometry |
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DOI:10.3969/j.issn.1004-4957.年份.月份 |
KeyWord:chlordimeform 4-chloro-2-methylaniline gas chromatography mass spectrometry(GC-MS) animal derived foods |
Author | Institution |
谢建军,陈捷,何曼莉,袁震宇,孙灵慧 |
广东出入境检验检疫局 |
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Abstract: |
A method was established for the determination of chlordimeform and its metabolite 4-chloro-2-methylaniline residues in foods of animal by GC-MS.Five kinds of foods derived from animal(e.g.tilapia muscle,chicken liver,pork,shrimp and beef ) were extracted with ethyl acetate in alkaline conditions(pH≥11.0).The extracts were purified with the graphitization carbon black cartridge(GCB SPE,250 mg/3 mL) and neutral alumina solid phase cartridge(Al2O3 SPE,2.0 g/3 mL),and then determined by GC-MS.Good linear relationships were obtained between the peak areas and the concentrations of chlordimeform and its metabolite 4-chloro-2-methylaniline within the range of 10-500 μg/L,with correlation coefficients of 0.999 1 and 0.998 7,respectively.The recoveries were in the ranges of 81%-119% for chlordimeform,and 80%-119% for 4-chloro-2-methylaniline,with RSDs(n=6) of 1.1%-11.7% and 2.0%-13.7%,respectively.The results showed that the quantitation limits for the two compounds were both 10.0 μg/kg.The proposed method was accurate,sensitive and high-efficient,and was applicable in the determination of chlordimeform and its metabolite in animal derived foods. |
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