Determination of 1£¬4-Dioxane Residues in Synthetic Detergents and Cosmetics by Headspace/Gas Chromatography-Tandem Mass Spectrometry

KeyWord:gas chromatography-tandem mass spectrometry  1,4-dioxane  multiple-reaction monitoring  synthetic detergent  cosmetics

Abstract:

      A headspace/gas chromatography-tandem mass spectrometric(HS/GC-MS/MS) method was established for the determination of 1£¬4-dioxane residues in synthetic detergents and cosmetics.The samples were mixed with water£¬then sodium chloride was added to produce the ¡°salting-out¡± effect.After oscillation£¬1£¬4-dioxane in sample was dissolved completely.The sample mixed with water was oscillated for 30 min at 80 ¡æ to get gas-liquid balance state and then the upper clear gas was prepared.The detection was carried out by GC-MS/MS under the multiple-reaction monitoring (MRM) mode.Good linearity in the concentration range of 0.1-100 mg/L was obtained£¬with a correlation coefficient of 0.999 8.The limit of detection(LOD) was 0.010 mg/kg and the limit of quantitation(LOQ) was 0.035 mg/kg.The average recoveries were in the range of 98%-103%£¬with relative standard deviations(RSDs) of 0.44%-2.1%.The accuracy£¬reliability and sensitivity of the method made it suitable for the determination of 1£¬4-dioxane in synthetic detergents and cosmetics.