Simultaneous Determination of 1-Propyl Alcohol£¬Diethylene Glycol£¬Propylene Glycol£¬Glycerol and Triethylene Glycol in Tobacco by Gas Chromatography-Mass Spectrometry

KeyWord:gas chromatography-mass spectrometry£¨GC-MS£©  tobacco  1-propyl alcohol  diethylene glycol  propylene glycol  glycerol  triethylene glycol

Abstract:

      A simple analysis method was developed for simultaneous determination of 1-propyl alcohol£¬diethylene glycol£¬propylene glycol£¬glycerol£¬triethylene glycol in tobacco by gas chromatography-mass spectrometry/selected ion mode£¨GC-MS/SIM£©with 1£¬4-butanediol as internal standard.40 mesh powdered tobacco sample was ultrasonic extracted by methanol for 60 min directly.Under the optimal conditions£¬the calibration curves were linear in the range of 1-100 ¦Ìg/mL£¬and the limits of detection£¨LODs£© were in the range of 0.05-0.48 ¦Ìg/mL.The spiked recoveries of analytes ranged from 90.2% to 103.7% with RSDs of 0.9%-3.0%.This method was suitable for the determination of 1-propyl alcohol£¬diethylene glycol£¬propylene glycol£¬glycerol£¬triethylene glycol in real tobacco samples with high sensitivity and convenient pre-treatment.