Effect of Ion Enrichment Pulse Power on Sensitivity Improvement of Time-of-flight Mass Spectrometry

KeyWord:sensitivity  ion enrichment pulse power  time-of-flight mass spectrometer(TOF MS)

Abstract:

      The effect of sensitivity enhancement of time-of-flight mass spectrometer(TOF MS) was studied with home made ion enrichment pulse power.Ion enrichment pulse power includes pulse signal generating module,amplification and isolation module,switching driving module,high voltage circuit module and load impedance matching module,outputing one medium voltage pulse signal and two-way symmetric high voltage pulse signals.In this work,TOF MS with electrospray ionization(ESI) was combined with laser desorption ionization(LDI) to debug ion enrichment pulse power.As a conclusion,the detection sensitivity of the instrument could be increased by 6-24 times for different samples when applying ion enrichment pulse power.