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Study on Interaction of 12-Tungstophosphoric Acid with Albendazole by Resonance Rayleigh Scattering,Second-order Scattering and Frequency Doubling Scattering Spectra and Their Analytical Application |
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DOI:10.3969/j.issn.1004-4957.年份.月份 |
KeyWord:resonance Rayleigh scattering second-order scattering frequency doubling scattering albendazole(ABZ) 12-tungstophosphoric acid |
Author | Institution |
LI Qin1*,TIAN Feng-ling,ZHENG Xiao-bo,LI Jin,YANG Ji-dong |
1.重庆市医药卫生学校;2.西南大学化学化工学院;3.重庆三峡学院化学与环境工程学院, |
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Abstract: |
A method for the determination of albendazole(ABZ) by resonance Rayleigh scattering(RRS),second-order scattering(SOS) and frequency doubling scattering(FDS) at the nanogram level using 12-tungstophosphoric acid(TP) was presented.It was found that ABZ could react with TP and form an ion-association complex by 3∶1 in pH 1.2 HCl medium,which induced the enhancement of RRS,SOS and FDS intensities.In certain ranges,the increments of scattering intensity(ΔI) were directly proportional to the concentrations of ABZ.The detection limits(3σ) for ABZ were 1.98 μg/L(RRS),3.75 μg/L(SOS) and 5.07 μg/L(FDS),respectively.The sensitivity of RRS method was higher than that of SOS and FDS methods.The optimum conditions of RRS method and the influencing factors were discussed.In addition,the composition of ion-association complex and the reaction mechanism were investigated.With a good selectivity,the method was successfully applied for the determination of ABZ in tablets and human urine samples with satisfactory results. |
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