Preparation and Characterization of Ethopabate Imprinted Microspheres Based on an Oxidation-reduction Initiating System

KeyWord:oxidation-reduction initiating  ethopabate  molecularly imprinted polymers  microspheres

Abstract:

      With the initialization of benzoyl peroxide and N,N-dimethyl aniline,the molecular imprinted polymer(MIP)microspheres were firstly prepared by using ethopabate as template,methacrylic acid as functional monomer and pentaerythritol triacrylate as crosslinking agent.The optimized porogen was acetonitrile and the optimum molar ratio of template,monomer and cross-linker was 1 ¡Ã6 ¡Ã20.After determining the concentrations of ethopabate and structurally related compounds by high performance liquid chromatographic method,the adsorption properties of the polymers were studied by static equilibrium adsorption,adsorption dynamics and selective binding experiment.The adsorption capacity and imprinting factor were calculated to be 15.0 ¦Ìmol?g-1 and 4.93,respectively.The physical and chemical properties of MIP microsperes were investigated with scanning electron microscope,Fourier transform infrared spectroscopy and differential scanning calorimeter.The result showed that the microspheres had uniform morphology,significantly high imprinting effect and good thermal stability.The above characteristics are favorable to the selective separation and purification of ethopabate from complex matrix using the microspheres.Therefore,the proposed oxidation-reduction system for initialization not only has the advantages of simple preparation,low cost and good specificity,but also offers a new paradigm for the preparation of molecular imprinted polymers.