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Study on Interaction between Loureirin and Human Serum Albumin by Pressure mediated Affinity Capillary Electrophoresis Method |
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DOI: |
KeyWord:affinity capillary electrophoresis loureirin A loureirin B cochinchinenin C human serum albumin(HSA) binding constant |
Author | Institution |
QIAN Kai,CHEN Xu,CHEN Qin* |
上海大学生命科学学院 |
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Abstract: |
The interactions of loureirin A(LA),loureirin B(LB) and cochinchinenin C(CC) with human serum albumin(HSA) under simulated physiological conditions(pH 74) were studied by pressure-mediated affinity capillary electrophoresis method(P-ACE).The binding constants were 0414×105,0252×105 ,1816×105 L/mol for LA,LB and CC,respectively.The results showed that P-ACE was a useful method to study the interaction between drug and protein. |
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