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Electrochemical Sensing of Dopamine Based on Poly(bromophenol blue)-Graphene Composite Modified Electrode |
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DOI: |
KeyWord:poly(bromophenol blue) graphene glassy carbon electrode dopamine electrochemical sensing |
Author | Institution |
CHEN Su-jing,LI Fang-fang,ZHONG Yun-xiu,WU Bai-yun,HU Dai-yu,ZHENG Wei,ZHENG Dong-yun* |
国家自然科学基金8726;中南民族大学中央高校基本科研业务费专项资金项目CZY14017,CTZ12001;中南民族大学科研团队项目 XTZ09002;中南民族大学大学生创新创业训练计划项目KYCXZ |
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Abstract: |
A poly(bromophenol-blue)-graphene(PBPB-GO) composite film modified glassy carbon electrode(GCE) was fabricated through a simple and controllable dropping and in situ electro polymerizing method,which was denoted as a DA electrochemical sensor.The result indicated that PBPB-GO composite film had a good catalytic effect on the electrochemical reduction of DA.The conductivities of bare GCE,GO/GCE,PBPB/GCE and PBPB/GO/GCE film were characterized through electrochemical impedance spectroscopy.The comparison results showed that the PBPB/GO/GCE had a lower resistance.Moreover,scanning electron microscopy was used to characterize the surface morphology of bare GO,GO/GCE and PBPB/GO/GCE,and the results indicated that PBPB-GO film had a loose and porous structure,which was beneficial to the enrichment of DA.Furthermore,the electrochemical reaction mechanism of DA on the PBPB/GO/GCE was studied and the results indicated that the electrochemical reaction of DA on the PBPB/GO/GCE was an adsorption controlled and proton participating process.The detection conditions were optimized,and the optimal electro polymerization cycles number was 15,the optimal quantity of GO(2 mg/mL) was 2 μL , and the optimal electrolyte solution was 0.1 mol/L phosphate buffer solution(pH 6.0).Under the optimal detection conditions,a wide linear range over DA concentration of 5.0×10-8-2.0×10-4 mol/L was obtained with a low detection limit of 1.0×10-8 mol/L.The DA electrochemical sensor showed good stability and reproducibility,high sensitivity and good selectivity,and was successfully applied in the detection of DA in dopamine injection. |
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