Determination of Residues of 21 Harmful Organic Solvents in Leather and Leather Products by Gas Chromatography-Mass Spectrometry Combined with Ultrasonic Extraction

KeyWord:ultrasonic extraction  gas chromatography-mass spectrometry£¨GC-MS£©  selected ion monitoring£¨SIM£©  leather  glycol ethers  amides  N-methylpyrrolidone

Abstract:

      A method was established to determine simultaneously the residues of 21 harmful organic solvents in leather and leather products by gas chromatography-mass spectrometry in selected ion monitoring mode£¨GC-MS/SIM£©.Residual harmful organic solvents in leather and leather products were ultrasonically extracted at 45¡æ,using ethyl acetate as extraction solvent.The extracts were purified with solid-phase extraction£¨SPE£© columns,and then analyzed by gas chromatography-mass spectrometry in selected ion monitoring mode£¨GC-MS/SIM£©.The content of each analyte was calibrated by the external standard method.At the condition of signal to niose£¨S/N£© of ten,the limits of quantitation£¨LOQs£© were 50¦Ìg/kg for ethylene glycol dibutyl ether£¨EGDBE£©,triethylene glycol dimethyl ether£¨TEGDME£©,diethylene glycol butyl ether£¨DEGBE£© and triethylene glycol ethyl ether£¨TEGEE£©,150¦Ìg/kg for N-methylformamide£¨MF£© and N-methylacetamide£¨MA£©,300¦Ìg/kg for formamide,and 100¦Ìg/kg for all the other fourteen compounds.The spiked average recoveries varied from 82.1% to 94.9% at three spiked levels with relative standard deviations£¨RSD£© of 1.6%-4.8%.The proposed method was simple,rapid,accurate and sensitive,and was suitable for the determination of residual harmful organic solvents in leather and leather products.