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| Synthesis and Antibacterial Properties of Imidazole Substituted Hydroxyl Quaternary Ammonium Salt |
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| DOI： |
| KeyWord:quaternary ammonium salt(QAS) N-methyl imidazole antibacterial properties cytotoxicity |
| Author | Institution |
| DU Min,WANG Chun-hua,HOU Gui-ge,CHEN Qin,LIU Wen-shuai,SUN Ju-feng |
滨州医学院药学院 |
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| Abstract: |
| In this paper,the quaternary ammonium salt(QAS-1) was prepared with N-methy imidazole and N-methyl diethanol amine.It was characterized by FT-IR,NMR and TOF-MS.Its antibacterial properties against S-aureus,α-H-tococcus,E-coli and P-aeruginosa were subsequently evaluated by paper disk method and shake culture method,which showed that it has a good antibacterial effect.Especially,the antibacterial effect against gram-negative bacteria(E-coli and P-aeruginosa) is more obvious and better than positive control(chlorhexidine). |
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