Detection of Promethazine Based on the Room Temperature Phosphorescence of MPA-capped Mn-doped ZnS Quantum Dots

KeyWord:MPA-capped Mn-doped ZnS  quantum dots(QDs)  room temperature phosphorescence(RTP)  promethazine(PMZ)

Abstract:

      Using 3-mercaptopropionic acid(MPA) as surface modifiers,Mn doped ZnS quantum dots with stable and good optical properties were synthesized via water phase method.In phosphate-buffered saline solution,the addition of promethazine could obviously quench the room temperature phosphorescence of MPA-capped Mn-doped ZnS quantum dots.Thus,a new method for the detection of promethazine was established.The quenched phosphorescence intensity(¦¤RTP) was linearly proportional to concentration of promethazine.The linear ranges of promethazine were 3.2-32 ¦Ìmol/L and 32-160 ¦Ìmol/L,with correlation coefficients of 0.998 and 0.999,respectively.The limit of detection for the method was 0.553 ¦Ìmol/L.This method was used to detect promethazine in human serum and urine samples with satisfactory results,and the recoveries ranged from 96.4%to 103.1%.