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| Research Progress on Application of Organic Mass Spectrometry in Structural Analysis of Antibody Drugs |
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| DOI： |
| KeyWord:organic mass spectrometry antibody structural analysis review |
| Author | Institution |
| ZHAO Yong-qiang，LIU Feng，SANG Zhi-hong，LI Mei，WANG Na，HE Kun* |
国家生物医学分析中心 |
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| Abstract: |
| With their targeting abilities，small sid-effects and low toxicity,antibody drugs could be directly combined with target specific，and they have broad application prospects in clinical practice.With its rapidness，high sensitivity and resolution，mass spectrometry(MS) has become an important means to analyze the structure of antibody，which provides a strong technical support for quality control and safety of the drug.In this paper，the rapid application development of organic mass spectrometry in the consistency of the amino acid sequence of antibody class，advanced structure and post translational modification（PTMs） are reviewed . |
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