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| Enantiomeric Separation of Raw Material and Intermediate of Cinacalcet Using Chiral Mobile Phase Additives |
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| DOI： |
| KeyWord:1-(1-naphthyl) ethylamine intermediate of cinacalcet 1-naphthalene vancomycin chiral mobile phase additive enantioseparation |
| Author | Institution |
| YAO Yan-yun,SUN Kong-chun,WANG Yong-xi,YANG Qian,WANG Le,CHEN Xi-long,SHEN Bao-chun* |
昆明医科大学药学院暨云南省天然药物药理重点实验室 |
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| Abstract: |
| An HPLC method was established for the chiral separation of cinacalcet raw material,1-(1-naphthyl)-ethylamine(compound-1) and intermediate of cinacalcet(compound 2),by using self made 1 naphthalene vancomycin as chiral stationary phase(Na-VAN CSP),and D-tartaric acid(D-Tar)，L-tartaric acid diethyl ester(L-TADE) and D-tartaric acid diethyl ester(D-TADE) as chiral mobile phase additives(CMPA),respectively.The influences of alcohol modifiers and CMPA types were studied.The mechanism of enantioseparation was also discussed.On Na-VAN CSP,compound 1 and 2 got certain degree of enantioseparation with different CMPA under normal phase conditions.When D-TADE was used as CMPA,the optimal enantioseparation for both compound 1 and 2 was obtained.The results showed that the size of alcohol modifier and the three dimensional configuration of CMPA played an important role in the enantioseparation. |
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