Electrochemical Detection of Chlorogenic Acid Based on the Enhancement Effect of Nb2O5/RGO Nanocomposites

KeyWord:nanocomposite  reduced graphene oxide  chlorogenic acid  Nb2O5 nanorod

Abstract:

      A simple and sensitive electrochemical method was developed for the determination of chlorogenic acid based on Nb2O5/reduced graphene oxide£¨RGO£© nanocomposites modified glassy carbon electrode£¨Nb2O5/RGO/GCE£©.Nb2O5/RGO composite was synthesized by a hydrothermal reduction using NbCl5 and graphene oxide£¨GO£©£¬and its morphology was characterized by scanning electronic microscopy£¨SEM£©.Electrochemical behaviors of chlorogenic acid on Nb2O5/RGO/GCE were studied by cyclic voltammetry£¨CV£© and square wave voltammetric(SWV) methods.The results showed that the Nb2O5/RGO composite displayed a remarkably enhanced electrochemical activity toward the oxidation of chlorogenic acid.Conditions influencing the detection process£¬such as pH value of buffer solution£¬scan rate and accumulation time£¬were optimized£®Under the optimized conditions, the oxidation peak current of chlorogenic acid has a good linear relationship with concentration of chlorogenic acid in the range of 5.0¡Á10-7-1.2¡Á10-5mol/L£¬with a detection limit£¨S/N=3£© of 2.0¡Á10-7mol/L.The proposed method was applied in the determination of chlorogenic acid in pharmaceutical products£¬and the spiked recoveries were in the range of 96.6%-101.5%£®With good sensitivity and stability£¬the developed method was successfully applied in the determination of chlorogenic acid in pharmaceutical products.