Simultaneous Determination of 22 Toxic Volatile Organic Solvent Residues in Cosmetics by Static Headspace/Gas Chromatography-Mass Spectrometry

KeyWord:static headspace  gas chromatography-mass spectrometry(GC-MS)  cosmetics  volatile organic compounds(VOCs)  determination

Abstract:

      Based on the Safety and Technical Standards for Cosmetics(2015),a staticheadspace/gas chromatography-mass spectrometric(SHS/GC-MS) method was established to analyze 22 volatile organic compounds(VOCs) residues,including dichloromethane,cis-1£¬2-dichloroethene,trans-1£¬2-dichloroethylene,2-chloro-1£¬3-butadiene,trichloromethane,1£¬2-dichloroethane,benzene,carbon tetrachloride,trichloroethylene,methylbenzene,tetrachloroethylene,chlorobenzene,ethylbenzene,tribromomethane,m-xylene,p-xylene,phenylethylene,o-xylene,isopropylbenzene,1£¬4-dichlorobenzene,1£¬2-dichlorobenzene and hexachlorobutadiene in cosmetics.The experimental conditions for SHS/GC-MS,such as headspace conditions,analytical conditions of GC,quantitative ion¡¯s selection and concentration of the samples were optimizedª±The cosmetic samples were extracted and cleaned up by headspace at 80 ¡æ for 30 min,determined and quantified by MS.22 kinds of VOCs had good linear relations in the range of 0.5-50 ng/mL with correlation coefficients higher than 0.99.The spiked recoveries ranged from 80.3% to 102.7%,with relative standard deviations(RSD) of 6.4%-9.9%.The limits of detection were in the range of 0.2-5.0 ng/g.This method had the advantages of simplicity,sensitivvity,accurancy, good reproducibility and stability,and was suitable for the screening and analysis of VOCs residues in cosmetics.ª±