Development of an Electrochemical Sensor for Detection of Ribavirin Based on In-situ Polymerization Molecularly Imprinted Film

KeyWord:ribavirin(RIB)  in-situ polymerization  molecular imprinting polymer (MIP)  electrochemical sensor

Abstract:

      A novel electrochemical sensor for the determination of ribavirin(RIB) was fabricated by molecularly imprinted technology£¬based on 3-aminobenzeneboronic acid as functional monomer£¬and ribavirin as target molecule.A molecularly imprinted polymers£¨MIPs£© membrane was synthesized on the surface of glassy carbon electrode in vacuum drying oven£¬by the formation principle of ring ester bond with boric acid and vicinal diol.The electrochemical behavior of the membrane was characterized by cyclic voltammetry(CV) and differential pulse voltammetry(DPV).Under the optimum conditions£¬the response of peak currents was linear to concentration of RIB in the range of 5.0¡Á10-8-1.0¡Á10-5 mol/L with a detection limit(S/N=3) of 1.5¡Á10-8 mol/L.The electrochemical sensor has the advantages of high sensitivity£¬good stability and high reproducibility£¬and could be uesd to detect RIB in food.