Dectection of Characteristic VOCs in Exhaled Breath of Lung Cancer Patients by Proton Transfer Reaction Mass Spectrometry

KeyWord:lung cancer patients  breath biomarkers  PTR-MS  VOCs  non-invasive analysis

Abstract:

      In this paper,a method was developed for the detection of characteristic VOCs in exhaled breath of lung cancer patients by proton transfer reaction mass spectrometry(PTR-MS).An improved breath analysis system was used for 32 normal volunteers and 40 lung cancer patients.The data were statistically analyzed by Mann-Whitney test and logistic regression.The results showed that analytes VOC 33£¬VOC 39 and VOC 45 might be the breath markers for lung cancer patients,while VOC 45 was significantly different between patients with small cell lung cancer and non-small cell lung cancer.The area derived from the receiver operating curve(AUC),under the logistic regression model,reached to 0.878,with the sensitivity and specificity of 85.5% and 63.5%,respectively,while through the Fisher discriminant model,the area from AUC reached to 0.822,with sensitivity and specificity of 82.5% and 62.5%,respectively.The two models were both statistically significant for lung cancer prediction.