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| Determination of Risperidone by Quantitative Nuclear Magnetic Resonance |
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| DOI： |
| KeyWord:risperidone nuclear magnetic resonance 1H NMR 19F NMR |
| Author | Institution |
| GUO Liu-cheng,HAO Hai-jun,DU Li-yue |
1.漯河医学高等专科学校药学系;2.上海医药工业研究院分析测试中心 |
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| Abstract: |
| Proton nuclear magnetic resonance(qHNMR) and fluorine nuclear magnetic resonance(qFNMR) were employed to determine the content of risperidone.The 1H NMR spectra were collected at 300 K within 4.0 s acquisition time,15 s relaxation delay and 32 scanning times.Proton signal peaks at δ 7.29-7.35 of risperidone and δ 6.02 of maleic acid were served as quantitative peaks.The 19F NMR spectra were obtained at 300 K by using 12 500.0 Hz spectral width and -43 662.7 Hz transmitter frequency offset(O1).4-bromo-2-fluorine acetanilide was employed as the internal standard.The results of qHNMR and qFNMR were generally consistent with that of the mass balance method.Therefore,quantitative nuclear magnetic resonance could be used for the quantitative determination of risperidone. |
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