Determination of the Migration of 27 Perfluorinated Compounds in Food Contact Materials by High Performance Liquid Chromatography-Tandem Mass Spectrometry

KeyWord:food contact materials  perfluorinated compounds  liquid chromatography-tandem mass spectrometry  migration

Abstract:

      A high performance liquid chromatography-tandem mass spectrometric£¨HPLC-MS/MS£© method was developed for the determination of the migration of 27 perfluorinated compounds in food contact materials using 3% acetic acid,10% alcohol,50% alcohol and olive oil as food simulants. Samples were soaked in 1 L different kinds of food simulants every 6 dm2 food contact materials according to (EU) Noª±10/2011.The water based simulant samples could be analyzed directly after filteration,and the olive oil stimulant samples should be extracted with acetonitrile before analysis. The simulated solution samples were separated on a C18 column with methanol-water as mobile phase,and analyzed under multiple reaction monitoring£¨MRM£© mode.The results showed that there existed good linearities£¨r£¾0ª±999 1£© for 27 perfluorinated compounds in the range of 1-1 000 ¦Ìg/L.The LOQs of PCFs were in the range of 0ª±28-9ª±85 ¦Ìg/kg in food simulants.The recoveries for 27 perfluorinated compounds in blank samples at two spiked levels of 10 and 100 ng ranged from 82ª±6% to 112ª±1% with relative standard deviations£¨RSDs£© of 2ª±2%-7ª±5%.