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Determination of Migration of Bisphenol A in Toys by High Performance Liquid Chromatography-Tandem Mass Spectrometry |
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DOI: |
KeyWord:bisphenol A migration toys high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) |
Author | Institution |
LI Han ke,ZHANG Qing,HUANG Ning shan,ZHOU Yi qi,LIN Jie cong,LIN Shao peng,TIAN Yong,YI Le zhou,LIU Chong hua,HUANG Li na |
广东检验检疫技术中心 |
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Abstract: |
A reliable and sensitive method was developed for the determination of BPA migration in toys by high performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS).The migration conditions based on European toy safety standard EN 71-10:2005 with water as simulant were modified.The sample was filtrated with syringe filters made of mixed cellulose esters(MCE),then directly determined by HPLC-MS/MS.Furthermore,the influences of syringe filters were intensively investigated,and the MCE filters had satisfactory BPA recoveries larger than 90%,whereas other filters made of polyamide(PA,nylon 66)and polyether sulfone(PES)resulted in significant loss of BPA.There existed a good linearity of the method in the range of 2-100 μg·L-1 with correlation coefficients(r2)greater than 0999.The limits of detection(LOD)were in the range of 030-052 μg·L-1,and the limits of quantitation(LOQ)were 100-172 μg·L-1.The spiked recoveries were in the range of 965%-106% with RSDs(n=7)of 20%-86%.The established method was successfully applied in the determination of migration of trace BPA in toys,avoiding the BPA loss caused by improper selection of syringe filters,which could meet the requirements for newly adopted BPA migration limit(004 mg·L-1)specified in the EU Directive 2017/898. |
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