Ion Mobility Mass Spectrometry and Its Applications in Lipids Analysis

KeyWord:lipids  ion mobility spectrometry£¨IMS£©  ion mobility mass spectrometry  isomer

Abstract:

      Lipids play an essential role in cells and tissues as they are basic molecules responsible for the functions including structure supporting,energy storage and signal transduction.Although traditional analytical methods in lipidomics could provide a relative high selective and sensitive identification for lipids,the diversity and similarity in lipid structures still pose a great challenge toward the global analysis of lipids in biological samples.Ion mobility spectrometry£¨IMS£© could separate the ions in buffer gas or electric field based on their mobility characteristics.The combination of IMS and traditional analysis approaches for lipids could not only attribute to the separation of sophisticated lipids,but also identify the lipid isomers,and thus improving the selectivity and resolution of lipid analysis.In this paper,various kinds of ion mobility mass spectrometry and their applications in lipids analysis were summarized,and their development prospects in future were expected as well.