Advance on Biomedical Application of Magnetic Nanoparticle Labeling Detection Technology in Point of Care Testing

KeyWord:magnetic nanoparticles  quantitative detection  biomedical diagnostics  point of care testing  superparamagnetism

Abstract:

      Magnetic labeling detection technology based on magnetic nanomaterials has the advantages of high sensitivity£¬wide linear range and easy operation£¬while the traditional labeling detection technology based on optical label usually could achieve qualitative detection or semi quantitative detection only.Most biological samples have low magnetic signal£¬leading to low background interference.Therefore£¬the magnetic labeling detection technology has shown higher sensitivity than optical labeling detection technology.It could not only carry out quantitative detection£¬but also reduce the pretreatment time.Point of care testing(POCT) could be performed at or near the sites of patient care£¬which is the trend of medical diagnosis.Magnetic labeling detection technology has an application potential in POCT£¬especially in biomedical use£¬such as detecting protein£¬nucleic acid£¬cell£¬pathogens and biological tissue.The latest research progress of magnetic nanoparticles in POCT is focused in this paper£¬and their applications in detecting protein£¬nucleic acid and several kinds of pathogens are discussed.Finally£¬the development direction and application prospect of POCT technology based on magnetic nanoparticles are outlined.