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Green Preparation of a γ-Aminobutyric Acid Bonded Silica Packing Material for Capillary Column and Its Performance Evaluation |
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DOI: |
KeyWord:γ aminobutyric acid bonded silica(Sil-GABA) green preparation capillary liquid chromatography |
Author | Institution |
ZHAO Shuang-li,LUO Fei-fei,ZHU Lu-qi,WANG Qing-jiang,HE Pin-gang |
School of Chemistry and Molecular Engineering,East China Normal University |
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Abstract: |
A γ aminobutyric acid bonded silica(Sil-GABA) stationary phase was prepared in a green medium with only water as solvent,which was characterized by Fourier transform infrared spectroscopy and elemental analysis.The separation mode and analytical performance of the Sil-GABA stationary phase were evaluated through a series of experiments when it was used as packing material for capillary column.Results showed that three nitrochlorobenzene positional isomers and seven sulfonamides were separated effectively on the Sil-GABA stationary phase with ammonium acetate as mobile phase in an aqueous liquid chromatography mode.Four benzoic acid compounds were separated with high concentrations of organic solvents as mobile phases in a hydrophilic chromatography mode.Additionally,three nitroaniline positional isomers were also separated in a reversed phase chromatography mode.Under the optimal conditions,the relative standard deviations(RSD) of the retention times for the sulfonamides were within 32%,indicating that the Sil-GABA column has a good reproducibility.The prepared Sil-GABA stationary phase could provide potential applications in capillary liquid chromatography with multiple retention mechanisms. |
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