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Simultaneous Determination of Specific Migration Amounts of 9 Antioxidants in Plastic Food Contact Materials by Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry |
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DOI: |
KeyWord:food contact materials and products antioxidants ultrahigh performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) |
Author | Institution |
DONG Ben,LI Zi-cheng,WANG Long-fei,BAO Lei,CHEN Yan-fen,ZHONG Huai-ning,LI Dan,ZHENG Jian-guo |
1.Guangzhou Customs District Technology Center,Guangzhou,China;2.NestleChina Food Safety Research Institute,Beijing,China |
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Abstract: |
In order to assess the migration risk of antioxidants in food contact materials and products,an ultrahigh performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) was established for the simultaneous determination of 9 antioxidants migration amounts in food contact materials and products.The separation of 9 antioxidants in the food simulant were performed on a C18 chromatographic column with 1 mmol/L ammonium fluoride-methanol as mobile phase.Under the electrospray ionization positive-negative mode,the antioxidants were detected in a multiple reaction monitoring mode,and quantified by the external standard method.Results indicated that this method exhibited a perfect performance in chromatographic separation.The calibration curves for the 9 antioxidants were linear in the range of 03-6 mg/L with their detection limits of 01 mg/L.The spiked recoveries ranged from 939% to 106% with relative standard deviations of 080%-93%.The method was suitable for the detection of migration amounts of 9 antioxidants in plastic food contact materials and products with the advantages of rapidness,high efficiency and good linear range. |
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