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Determination of α-Chlorotoluene in Cos? metics by Headspace Gas Chromatogra? phy-Mass Spectrometry |
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DOI: |
KeyWord:α-chlorotoluene ?cosmetics ?benzalkonium chloride ?thermal degradation ?headspace gas chromatography-mass spectrometry (HS-GC-MS) |
Author | Institution |
LIU Hua-chun, LIANG Wen-yao, WANG Ji-cai, XIA Ze-min, XIONG Xiao-ting, PENG Rong-fei, TAN Jian-hua |
1. Guangzhou Center for Disease Control and Prevention,Guangzhou ,China;2. Guangzhou Quality Supervision and Testing Institute,National Quality Supervision and Testing Center for Cosmetics(Guangzhou), Guangzhou ,China |
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Abstract: |
A method was developed for the determination of α-chlorotoluene in cosmetics containing benzalkonium chloride. Firstly, the thermal decomposition products of benzalkonium chloride was analyzed by gas chromatography-mass spectrometry(GC-MS). A phenomenon was confirmed that benzalkonium chloride and similar compounds will decompose into α-chlorotoluene at the inlet of GC-MS. Then, a new analytical method for α-chlorotoluene in cosmetics was developed by a headspace injection mode of gas-liquid equilibrium. The headspace sampling parameters, chromatographic separation and mass spectrometry conditions were optimized. The equilibrium temperature and time for headspace sampler were set at 80 ℃ and 30 min, respectively. The sample was dissolved with 8 mL water and 1.0 g sodium chloride in headspace bottle. The analytes were separated on an HP-INNOWax column(60 m × 0.25 mm × 0.25 μm), then detected in selectedion monitoring mode and quantified by external standard method. Results showed that the standard curves for α-chlorotoluene were linear over the concentration range of 0.01-5.00 μg/mL with linear correlation coefficients(r) of 0.999. The detection limits and quantification limits of the method were 0.02 μg/g and 0.05 μg/g, respectively. The spiked recoveries ranged from 91.3% to 98.8% with relative standard deviations(RSDs) of 1.5%-4.9%. The method is simple, rapid, high sensitive and specific, and it is suitable for the determination of α-chlorotoluene in cosmetics. |
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