Determination and Influencing Factors of Migration of Primary Aromatic Amines in PA/CPP Retort Pouch

KeyWord:polyamide/cast polypropylene£¨PA/CPP£©  primary aromatic amines£¨PAAs£©  liquid chromatography-tandem mass spectrometry£¨LC£­MS/MS£©  food simulants  migration

Abstract:

      A liquid chromatography£­triple quadrupole tandem mass spectrometry£¨LC£­MS/MS£© was developed for determination of the migration amounts of three primary aromatic amines£¨PAAs£© including 2£¬4-diaminotoluene£¬2£¬6-diaminotoluene£¬4£¬4¡ä-diaminodipheny/methane in Polyamide/cast polypropylene£¨PA/CPP£© retort pouch£®Results showed that this method has the advantages of simple operation and high sensitivity£¬which meets the specific migration limit£¨SML£© detection requirements for individual PAAs revised in the European Regulation£¨EU£© No 10/2011. This method was used to detect the migration amounts of PAAs in 30 kinds of PA/CPP retort pouches under the condition of 100 ¡æ for 2 h£®It was found that 4£¬4¡ä-MDA was detected in all retort pouches£¬and the migration amounts of 4£¬4¡ä-MDA in 17 kinds of retort pouches were higher than its SML£¨0.002 mg/kg£©£®Afterwards£¬the influence of heat treatment on retort pouches and the influences of storage and transportation on the migration of 4£¬4¡ä-MDA in retort pouches were investigated£®The results showed that heating temperature and heating time might lead to the increase of isocyanate monomer in retort pouches£¬and finally promote the migration of PAAs£®During the simulation of the storage and transportation process£¬it is found that the increase in ambient temperature and the vibration during transportation could promote the migration of 4£¬4¡ä-MDA in retort pouches. The amount of 4£¬4¡ä-MDA migration might exceed the standard if the sample bag was exposed to an ambient temperature of 60 ¡æ for 5 d£¬and there may be food safety issues.