Simultaneous Determination of the Migration of 20 Photo Initiators in Food Contact Inks by UPLC£­MS/MS

KeyWord:photo initiator  migration  food contact material  ultra-high performance liquid chromatography£­tandem mass spectrometry

Abstract:

      An ultra-high performance liquid chromatography£­tandem mass spectrometry was established for simultaneous determination of the migration of 20 photo initiators in food contact inks in order to assess the migration risk of photo initiators in food contact inks£®The sample was separated using a mixture of 0.1%£¨volume fraction£© formic acid and methanol solution as the mobile phase by gradient elution. 20 kinds of photo initiators in the food simulants were detected after the migration experiment£¬and the quantitative and qualitative ions of the target were monitored in multi-reaction monitoring mode£®Results showed that the chromatographic separation effects of this method for the photo initiators were good£¬and there existed good linear relationships for each substance in the concentration range of 0.02£­0.5 mg/L£¬with their detection limits and quantitation limits of 0.01 mg/kg and 0.02 mg/kg£¬respectively£®The spiked recoveries ranged from 87.1% to 104%£¬with relative standard deviations£¨RSD£© of 2.1%£­8.6%£®A total of 4 types of photo initiators were detected in 10 samples£®This method is simple£¬sensitive and accurate£¬and is suitable for the detection of the migration amount of 20 photo initiators in food contact inks.