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| Determination of Acrylamide Migration in Paper-based Food Contact Materials by Ultra Performance Liquid Chromatography－Tandem Mass Spectrometry |
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| DOI： |
| KeyWord:ultra performance liquid chromatography－tandem mass spectrometry food contact materials acrylamide migration |
| Author | Institution |
| QIAN Kai，LI Wei-tao，GE Wen-xiu，LIU Li-na，CHEN Ming，LI Jin-feng |
1. Changzhou Safety Testing Center for Entry－Exit Industrial and Consumable Products，Changzhou ，China; 2. Nanjing Customs Testing Center for Dangerous Goods and Packaging，Changzhou ，China |
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| Abstract: |
| An ultra performance liquid chromatography－tandem mass spectrometry was established for the determination of acrylamide in order to evaluate and study the compliance and risk of acrylamide migration in paper-based food contact materials．In this method，the test solution was separated on an Agilent Poroshell 120 SB－Aq column（4.6 mm × 100 mm，2.7 μm） with 0.1% formic acid（volume fraction） and methanol solution（9∶1） as mobile phases．The MS detection was performed in positive electrospray ionization（ESI） under multiple reaction monitoring（MRM） mode．The method validation results indicated that there were good linear relationships for acrylamide between the content and chromatographic peak areas in different food simulants．The linear relationships were obtained in the range of 5.0－100.0 μg/L for water-soluble food simulants and 10.0－200.0 μg/kg for oily food simulant，with their limits of detection（LOD） of 1.0 μg/L and 5.0 μg/kg，respectively．The spiked recoveries varied from 90.0% to 113%，with relative standard deviations（RSD，n = 6） of 0.40%－4.6%．The established method was applied to the determination of three kinds of paper-based food contact materials．Results showed that paper straw has higher acrylamide migration and more potential food safety risk than the other two materials. |
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