A Study on Consistency Evaluation of Preparation of Sinomenine Hydrochloride Based on Multi-source Data Fusion Technique

KeyWord:sinomenine hydrochloride  multi-source data fusion technique  near-infrared spectroscopy  Raman spectroscopy  process change

Abstract:

      To investigate the quality difference of sinomenine hydrochloride prepared with different extraction solvents and explore the feasibility of changing the extraction process£¬the quality of sinomenine hydrochloride samples prepared by benzene and acid water percolation£­chloroform extraction were systematically evaluated using near-infrared spectroscopy£¬Raman spectroscopy combined with multi-source data fusion technique£®Subsequently£¬the potential effects of the two solvents on product were compared£®The overall quality of the samples were characterized with the different statistics named similarity matching value£¨SMV£©£¬Hotelling T2 and DModX£¬under three fusion modes of low£¬medium and high levels£®Under the low level fusion mode£¬the results showed that the DModX values of nine samples exceeded the control limit£®Under the medium level fusion mode£¬the SMV of one sample was lower than the control limit£®Under the high level fusion mode£¬the SMVs of three samples were below the control limit£¬and the DModX values of five samples were above the control limit. Compared with the samples obtained by acid water percolation£­chloroform extraction£¨obtained from manufacturer A£©£¬the quality consistency of the samples prepared by benzene£¨obtained from manufacturer B£© and chloroform extraction£¨obtained from manufacturer C£© is good£¬except that several samples need arbitration analysis for quality confirmation£®In the process of sinomenine extraction£¬chloroform with low toxicity could be used to replace benzene which is harmful to human health£®The study is aimed to develop a new strategy for evaluating the quality difference of traditional Chinese medicine products before and after the change of preparation process£®