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Recent Progress of Proteomics-driven Precision Medicine |
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DOI: |
KeyWord:proteomics ?mass spectrometry ?biomarker ?proteomics-driven precision medicine(PDPM) |
Author | Institution |
ZHANG Lei,WANG Xiao-yu,ZHANG Ying,LU Hao-jie |
1. Institutes of Biomedical Sciences,Fudan University,Shanghai ,China;2. NHC Key Laboratory of Glycoconjugates Research,Fudan University,Shanghai ,China |
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Abstract: |
Proteins involve in virtually all cell functions and participate in a variety of metabolic and physiological processes.Proteomics,which systematically analyzes the protein expression levels,modification states of proteins,and intracellular protein-protein interactions,provides a global perspective on how these molecules changes at different stages of disease occurrence and development.Recently,clinical proteomics has been proven to play a significant role in early diagnosis,prognosis,and monitoring of disease development.The concept of proteomics-driven precision medicine has been proposed thereby.In this review,the progress of proteomics-driven precision medicine(PDPM) and its application in the studies of major diseases are summarized. |
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