Effects of Micro/Nano Patterned Surfaces on Cell Behaviors

KeyWord:micro/nano structure  ?patterned surface  ?cell orientation  ?regenerative medicine

Abstract:

      In the field of regenerative medicine£¬the regulation effect of materials on cell growth and tissue repair has always been a critical issue£®With the development of surface patterning technique£¬it has become possible to prepare regular£¬controllable£¬and diverse patterned areas on the surface of materials£®Therefore£¬patterning technque is widely used in related disciplines such as regenerative medicine£¬tissue engineering and cell diagnosis£®Micro/nano surface patterning methods are used to change the chemical properties and topological structures of materials£¬so as to achieve the regulatory effect on cell adhesion£¬migration£¬proliferation£¬apoptosis£¬gene expression and cell differentiation£¬which have attracted more and more attention£®This type of research is currently quite rich and diverse£¬involving a variety of micro/nano structures£¬substrate materials£¬modified materials£¬cell types and cell behavior. The micro/nano surface patterning methods mainly used in the current experiments are introduced in this article£®Meanwhile£¬the research work in the field of material micro/nano structure regulation of cell behavior is also summarized from the aspects of anisotropic topological structure£¬isotropic topological structure and composite structure£®Finally£¬the specific relationship between cell behavior and growth environment is summarized£¬so as to provide references for the design of scaffolds and implants used in regenerative medicine£®