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| Progress on In-situ DNA Self-assemblies for Cellular Fluorescence Imaging Analysis |
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| DOI： |
| KeyWord:in-situ DNA self-assembly ?fluorescence imaging ?living cell ?trigger mechanism |
| Author | Institution |
| WANG Si-cheng，HAN Ting，WANG Guang-feng |
1. Key Laboratory of Chem－Biosensing and Key Laboratory of Functional Molecular Solids of Anhui Province，College of Chemistry and Materials Science，Anhui Normal University，Wuhu ，China;2. Department of Chemistry，University of North Texas，Denton 76201，America |
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| Abstract: |
| DNA self-assemblies play an increasingly significant role in biosensing，drug delivery and therapy due to their minimal toxicity，high biocompatibility and built-in features．Compared to most natural polymers or synthetic fibers，these DNA molecules could be relatively strong while also modifiable through sequence variation．By simply attaching to a polymer as a side chain，the secondary structure formed could endow the DNA structure with designable responsiveness to something like metal ions，proteins，pH，DNA，RNA，and some other small signal molecules（such as ATP） response to achieve some functional self-assemblies．In this review，the most recent progress of DNA self-assembly is introduced．The focus is on the initiator to distinguish the trigger mechanism and their fluorescence imaging applications. |
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