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Analysis on Electron Impact Fragmentation Characteristics of Indazole-3-carboxamide Analogues Synthetic Cannabinoids |
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DOI: |
KeyWord:new psychoactive substances synthetic cannabinoids indazole-3-carboxamide gas chromatography mass fragmentation characteristics |
Author | Institution |
XU Fang-min,LI Hai-bo,WEI Wan-li,WANG Rui-hua,LIU Ling-yun,LI Qiang |
1. Institute of Forensic Science,Public Security Bureau of Jiangyin,Jiangyin ,China; 2. Institute of Forensic Science,Public Security Bureau of Changzhou,Changzhou ,China; 3. Institute of Forensic Science,Public Security Bureau of Wuxi,Wuxi ,China; 4. Institute of Forensic Science, Ministry of Public Security,Beijing ,China |
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Abstract: |
A gas chromatography-mass spectrometry(GC-MS) was applied to investigate the mass fragmentation characteristics of 9 indazole-3-carboxamide analogues synthetic cannabinoids in electron ionization(EI),including MDMB-CHMINACA,5F-AB-PINACA,5F-AMB,AB-CHMINACA,AB-FUBINACA,AB-PINACA,MDMB-FUBINACA,AMB-FUBINACA and ADB-BUTINACA.The obtained mass spectra were analyzed and the EI fragmentation patterns of indazole-3-carboxamide analogues synthetic cannabinoids were speculated.Results showed that in the EI mode,the C—N cleavage of the amide group connected to the indazole ring at position 3 is the main fragmentation pathway,and the McLafferty rearrangement was happened during the fragmentation.The main fragmentation ions and mass fragmentation characteristic of indazole-3-carboxamide analogues synthetic cannabinoids in EI modes were summarized in this paper,which is useful for identification on the new psychoactive substances of unknown indazole-3-carboxamide analogues synthetic cannabinoids in practical work. |
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