Research Progress on Electrochemical Biosensors for SARS£­CoV£­2 Detection

KeyWord:severe acute respiratory syndrome coronavirus 2£¨SARS£­CoV£­2£©  electrochemical biosensor  spike protein  nucleocapsid protein  ribonucleic acid£¨RNA£©  COVID£­19

Abstract:

      Electrochemical sensors have attracted widespread attention in the field of severe acute respiratory syndrome coronavirus 2£¨SARS£­CoV£­2£© detection owing to their characteristics of high sensitivity£¬portability£¬high robustness£¬miniaturization£¬low cost£¬no pretreatment and rapid detection£®Firstly£¬the components of SARS£­CoV£­2£¬the causative bacterium of COVID£­19 are roughly described in this paper£®Secondly£¬the researches on three electrochemical biosensors that can specifically detect SARA£­CoV£­2 based on the spike protein on the surface£¬internal nucleocapsid protein and ribonucleic acid£¨RNA£© are reviewed£®Moreover£¬the key parameters such as limit of detection£¬time and dynamic detection range of the three types of electrochemical biosensors are comprehensively analyzed. Meanwhile£¬the advantages and disadvantages of electrochemical biosensors are analyzed when compared with other methods for SARA£­CoV£­2 detection£®Finally£¬it is pointed out that the improvement of electrochemical biosensor performance could be realized in the future by optimizing detection electrode materials£¬reaction conditions and modification detection probes£¬which is of important significance for early detection£¬early isolation and early treatment of COVID£­19 patients£¬and even providing a strong support for the design of rapid diagnosis of COVID£­19 equipment£®