Determination of Migration of Endocrine Disruptors in PVC Children Products by Liquid Chromatography£­Tandem Mass Spectrometry with Magnetic Graphene Oxide Dispersive Solid Phase Extraction

KeyWord:liquid chromatography£­tandem mass spectrometry£¨LC£­MS/MS£©  magnetic graphene oxide  endocrine disruptors  migration  PVC children products

Abstract:

      A method based on liquid chromatography£­tandem mass spectrometry with magnetic graphene oxide dispersive solid phase extraction was developed for the determination of 14 kinds of endocrine disruptors in PVC children products£®The samples were soaked in simulated sweat and simulated saliva£¬and the endocrine disruptors in migration fluid were enriched by magnetic graphene oxide dispersive solid phase extraction£¬determined by liquid chromatography£­tandem mass spectrometry£¬and quantified by matrix external standard method£®The results showed that 14 kinds of endocrine disruptors could be enriched and purified by a 15 min adsorption of 10 mg magnetic graphene oxide£¬and followed by a 15 min desorption of 3 mL acetone containing 1% formic acid£®There were good linear relationships for the 14 analytes in the respective concentration ranges£¬with their correlation coefficients of 0.990 1£­0.999 2£®The limits of detection and limits of quantitation were in the range of 0.1£­0.5 ¦Ìg/L and 0.3£­1.5 ¦Ìg/L£¬respectively£®Meanwhile£¬the spiked recoveries ranged from 80.2% to 105%£¬with relative standard deviations£¨RSDs£© of 1.0%£­6.8%£®The method is simple£¬rapid and reproducible£¬and it could be used to determine the migration of endocrine disruptors in PVC children products£®