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| Progress on Single-cell and Spatial Transcriptome Analysis |
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| DOI： |
| KeyWord:single-cell sequencing transcriptome multi-omics spatial transcriptome research progress |
| Author | Institution |
| XU Xing，CAI Lin-feng，ZHANG Qian-nan，YANG Qi-zheng，LIANG Shan-shan，LI Ming-yin，LI Chong，YANG Chao-yong |
1. College of Chemistry and Chemical Engineering，Xiamen University，Xiamen ，China; 2. Institute of Molecular Medicine，Shanghai Jiao Tong University，Shanghai ，China |
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| Abstract: |
| Heterogeneity in single cells has important implications for embryo development，neurogenesis and cancer progress．Single-cell transcriptome sequencing，decoding transcript sequences within cells based on high-throughput sequencing technology，can provide reliable and accurate research methods for cellular heterogeneity study to reveal the rule of biological development and disease progress．Different methods for single-cell transcriptome sequencing，single-cell multi-omics sequencing and spatial transcriptome analysis in recent years are summarized in this review．Challenges and perspectives of single-cell and spatial transcriptome analysis are discussed．Low-cost，all-round，high-throughput，high-resolution single-cell spatially multi-omics analysis is helpful to construct comprehensive and accurate single-cell atlas. |
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