Research Progress on Bioanalytical and Sensing Applications of Cerium Oxide

KeyWord:cerium  ceria  sensor  electrochemical  colorimetric  fluorescent  chemiluminescent

Abstract:

      Cerium is one of the most active rare earth elements in the lanthanide family£¬and cerium oxide has been widely used in fields of polisher£¬decolorizer£¬catalyst and luminescence enhancer£¬etc£®The spontaneous redox cycle between Ce3+/Ce4+ may generate many oxygen vacancies£¨V?£© on the cerium oxide crystal surface£¬which can accelerate the charge transfer in the reaction and make cerium oxide have high catalytic activity and oxygen storage and release capacity£®The mixed-valence spontaneous redox cycle and the resulting oxygen vacancies have a significant impact on the properties of cerium oxide£¬allowing it to exhibit unique biomedical activities such as antibacterial£¬anti-inflammatory£¬anti-tumor and enzyme mimicking activities£¬which could be used in the treatment of many diseases£®In addition£¬cerium oxide could be used alone or doped and compounded with other materials to build sensitive sensing materials for the analysis and detection of a variety of substances£¬which has become a hot spot for domestic and international research£®In this review£¬the theoretical basis of cerium oxide as a sensing material is firstly clarified£¬while the research progresses of cerium oxide sensing in the fields of electrochemical sensing£¬colorimetric sensing£¬fluorescence sensing and chemiluminescence sensing at home and abroad are then summarized£¬and finally£¬the status of research and development of cerium oxide sensors are summarized£¬and an outlook for the future development of high-performance sensors is provided.