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Portable Detection of Ca2+ Using Writing Robots Drawing Paper-based Microfluidic Chips |
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DOI: |
KeyWord:paper-based microfluidic chip writing robot hydrogel rapid detection visual quantitative detection |
Author | Institution |
LIU Xu,GAO Guo-wei,HU Jing-fang,ZHANG Kai-yu,LI Yan-sheng |
1. Key Laboratory of Sensors,Beijing Information Science and Technology University,Beijing ,China;
2. MOE Key Laboratory of Modern Measurement and Control Technology,Beijing Information Science and Technology University,Beijing ,China;
3. Joint State Key Laboratory of Sensing Technology,Shanghai Institute of Microsystems and Information Technology, Chinese Academy of Sciences,Shanghai ,China |
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Abstract: |
The paper-based microfluidic chips are a kind of paper-based chips,which have the advantages of excellent performance,low price,safety and portability.However,the preparation technology for paper-based microfluidic chips mostly depends on the professional and expensive equipments,which limits their development to a certain extent.And it is not conducive to the commercialization process for paper-based microfluidic chips.In this paper,a paper-based microfluidic chip with hydrogel valve was developed by using a low-cost,simple home writing robot to draw a smart hydrogel with sensitive properties on a paper base.In order to verify the feasibility of the preparation method,Ca2+ was used as a model target.Results showed that the paper-based microfluidic chip prepared by this method could achieve the quantitative detection of Ca2+ solutions in the concentration range of 0.1-50 mmol/L with the naked eye,which has good usability and reproducibility.Meanwhile,a ILX506 CCD sensor was used to design and optimize the digital display device of the paper-based microfluidic chip so as to realize the automatic reading function for the measurement results of paper-based microfluidic chip.The experimental results showed that this method could be used for the rapid and convenient preparation of multiple paper-based microfluidic chips at low cost.The preparation method provides a new research idea for the ubiquitous preparation of paper-based microfluidic chips,which has a good promotion prospect in those developing regions. |
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