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| Study on Screening of 35 Volatile Allergic Fragrances in New Mosquito Repellent Products and Their Volatilization Patterns |
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| DOI： |
| KeyWord:headspace gas chromatography－tandem mass spectrometry（GC－MS/MS） mosquito repellent product allergic fragrance volatilization patterns |
| Author | Institution |
| LI Hong-yan，HU Yu-xia，LI Chang-yu，WANG Jin |
1. Zhejiang Institute of Product Quality and Safety Science，Hangzhou ，China; 2. Zhejiang Institute of Economics and Trade，Hangzhou ，China; 3. Zhejiang Fangyuan Testing Group Co.，Ltd，Hangzhou ，China |
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| Abstract: |
| A headspace/gas chromatography－tandem mass spectrometry（HS/GC－MS/MS） was established for the screening of 35 volatile allergic fragrances in different new mosquito repellent products．The new mosquito repellent products included mosquito repellent stickers，mosquito repellent buckles and mosquito repellent bracelets，etc．35 substances were separated by a medium polarity Agilent DB－17MS column and detected with electron impact ion source（EI） under multiple reactions monitoring（MRM） mode．Two different headspace equilibrium temperatures of 40 ℃ and 100 ℃ were selected．The screening results for 37 new mosquito repellent products showed significant differences at different temperatures．A total of 14 volatile allergic fragrances were detected at 40 ℃，including α-pinene，β-pinene，D-limonene，benzaldehyde，terpinolene，linalool，DL-menthol，D-camphor，linalyl acetate，citronellol，methyl salicylate，citral，β-caryophyllene and cinnamaldehyde．In addition，another 12 allergic fragrances at 100 ℃ were found，including terpineol，geraniol，carvone，4-methoxyphenol，4-tert-butylphenol，trans-anethole，eugenol，benzalacetone，lily aldehyde，farnesol，α-amylcinnamyl alcohol and benzyl benzoate．Taking the mosquito repellent stickers and mosquito repellent buckles for children for examples，the response intensities of the target compounds at different headspace temperatures were semi-quantitatively determined．The results showed that the response intensities for the 8 volatile allergic fragrances at 40 ℃ were less than those at 100 ℃．37 samples were semi-quantitatively analyzed at the equilibrium temperature of 40 ℃．The results indicated that 9 volatile allergic fragrances，i.e．α-pinene，β-pinene，D-limonene，benzaldehyde，terpinolene，linalool，DL-menthol，D-camphor and methyl salicylate were detected in most samples，in which the maximum response intensities for α-pinene and D-limonene were more than 106．The volatilization patterns for volatile allergic fragrances in new mosquito repellent products were also studied at 40 ℃．The contents of the mosquito repellent stickers and mosquito repellent buckles kept at 40 ℃ for different times were determined，of which 5 volatile allergic fragrances，including α-pinene，β-pinene，D-limonene，DL-menthol and D-camphor with high detection rates and strong response intensities were investigated. Among the 5 analytes，α-pinene，β-pinene and D-limonene showed significant downward trends from 0 hour to 12 hours，which decreased to 20%－21%．The response intensities for both DL-menthol and D-camphor were still more than 40% of those at the beginning after 72 hours．This study provides a technical reference for the subsequent quantitative analysis and risk assessment of multiple allergic fragrances in mosquito repellent products. |
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