|
| Quality Control of Compound Glycyrrhizin for Injection by Near Infrared Spectroscopy |
| |
| View Full Text Download reader |
| DOI： |
| KeyWord:near infrared spectrum（NIRS） quantitative model compound glycyrrhizin for injection |
| Author | Institution |
| WANG Yi-cheng，GUO Zhi-yong，YAN Yu，XUE Hong-bao，CHEN Peng，GONG Wen-wu |
1. School of Public Foundation，Bengbu Medical College，Bengbu ，China; 2. Department of Production Technology，Anhui Hongye Pharmaceutical Co. Ltd.，Bengbu ，China; 3. Fifth Precinct of Medical Products Administration in Anhui Province，Bengbu ，China |
|
| Hits: 1784 |
| Download times: 1215 |
| Abstract: |
| In this paper，a quantitative analysis model was established by partial least squares method（PLS），based on the contents of glycine，glycyrrhizin and cysteine hydrochloride in compound glycyrrhizin by collecting near infrared spectrum（NIRS） of 70 batches of samples，and verified．Results showed that linear correlation coefficients（R） of the established model for glycine，glycyrrhizin and cysteine hydrochloride were 0.999 54，0.947 01 and 0.999 95，while the root mean squared error of correction set（RMSECs） were 0.289，0.098 0 and 0.001 07，respectively．Furthermore，the mean relative deviations between the reference values and the predicted values of the three components in 13 batches of samples were 0.41%，0.72% and 0.86%，respectively，and there was no significant difference in the T test（P > 0.05）. |
| Close |