Advances in Metabolism of New Psychoactive Substances Based on Mass Spectrometry

KeyWord:new psychoactive substance  metabolism  mass spectrometry  review

Abstract:

      New psychoactive substances£¨NPSs£© have been proliferating in recent years£¬posing a threat to public health and social stability through contributing to social issues like crime£®NPSs are quickly metabolized in the human body£¬while mass spectrometry could be used to effectively determine a substance¡¯s ingestion by detecting its distinctive metabolites£®The in vitro and in vivo metabolic studies of NPSs in the last five years are reviewed in this paper by searching£¬organizing£¬and discussing the pertinent literature£®The applicability£¬benefits and drawbacks of various methods are also summarized and compared to data from real human samples£®Finally£¬the development trend of metabolic research methods is looked ahead with a view to providing references for metabolic studies of NPSs such as metabolite identification and metabolite inference.