Determination of 16 Phthalate Plasticizers in the Extracts of Plastic Components Used in the Production of Fludeoxyglucose £Û18F£Ý Injection by Liquid£­Liquid Extraction/Gas Chromatography£­Mass Spectrometry

KeyWord:gas chromatography£­mass spectrometry  liquid£­liquid extraction  plasticizers  fludeoxyglucose £Û18F£Ý injection  plastic components

Abstract:

      A method based on liquid£­liquid extraction£¨LLE£©/gas chromatography£­mass spectrometry£¨GC£­MS£© was developed for the determination of 16 phthalate plasticizers£¨PAEs£© in the extracts of plastic components used in the production of fludeoxyglucose£Û18F£Ý injection. According to the production process£¬the simulated solvent for extraction experiments was a mixture of 5% ethanol and 5% acetonitrile£¬and the extraction temperature was simulated at 40 ¡æ. The extracts were separated on a Thermo TG£­5 SIL MS column£¬and analyzed in selected ion scanning mode£¨SIM£©. The instrument conditions and the extraction conditions were optimized to determine the most suitable pre-treatment method and instrument conditions. Under the optimized experimental conditions£¬the peak areas of 16 PAEs were linearly correlated in the range of 50£­500 ng/mL£¬with correlation coefficients£¨r£© not less than 0.990 6. The limits of detection£¨LODs£© and limits of quantitation£¨LOQs£© were 10 ng/mL and 30 ng/mL£¬respectively. The average recoveries ranged from 83.0% to 114% with relative standard deviations£¨RSDs£¬n = 6£© of 1.9%£­4.2% when dichloromethane was used as the extraction solvent. 16 PAEs did not exceed the analytical evaluation threshold£¨AET£© when the extracts were determined by this method. The method is simple and specific£¬and it could be used to study the compatibility of plastic production components for fludeoxyglucose £Û18F£Ý injection.